Low Blood Cell Counts Could Be Treated by Regulating Stem Cells.

Megakaryotes may hold the ability to regulate the amount of blood that stem cells produce.

According to new research from the Stowers Institute for Medical Research, hematopoietic stem cells [stem cells that produce blood] are directly regulated by megakaryocytes, the blood cells responsible for healing wounds.  The researchers found that megakaryotes produce two growth factors; one that signals for hematopoietic stem cells to proliferate, and one that keeps them in an inactive state.  This relationship controls the amount of blood being produced in the body. Continue reading

Blood Cells Generated by Modified Stem Cell Differentiation

Researchers have identified two transcription factors that induce stem cells to differentiate into blood cells.

A research group led by Dr. Igor Slukvin, MD PHD, from University of Wisconsin-Madison has identified two transcription factors responsible for the differentiation of stem cells into numerous types of white and red blood cells.  The team made use of messenger RNA to overexpress the two transcription factors, which allowed them to generate 30 million blood cells for every million stem cells, without the use of a virus or altering the genetic structure of the blood. Continue reading

Multiple Sclerosis Patients Reboot Immune System with Stem Cells

Biologists have successfully reset the self-destructive immune systems of Multiple Sclerosis patients by utilizing autologous stem cells.

In a recent publication, biologists in the Immune Tolerance Network have used autologous [the patient’s own] stem cells to refurbish the immune systems of Multiple Sclerosis [MS] patients to no longer favor autoimmunity. The ITN researchers suppressed the patients’ immune systems, transplanted the stem cells, and in a 12 month follow-up, identified key distinctions between the patients’ T-cells before and after the transplant, indicating that the procedure was a success. Continue reading