In a recently published study from the Hallym University College of Medicine, researchers have applied mesenchymal stem cells [MSCs] to animal models afflicted with global cerebral ischemia [GCI] to successfully reduce the associated neuronal damage. When compared to those that received no treatment, animals that received MSCs displayed a significant decrease in cell death, inflammation to the brain, and disruption of the blood brain barrier. Continue reading
In a pilot study conducted by the Imperial College Healthcare NHS Trust, five patients received transplants of their own [autologous] stem cells directly into their brains only seven days after a severe stroke. Although the trial was designed primarily to assess the safety of such a procedure, the patients showed significant signs of recovery considering the typical lethality of the strokes. Continue reading
Researchers from the University of Adelaide, led by Dr. Kylie Ellis, have discovered that dental pulp stem cells [DPSC] have the ability to differentiate into complex networks of cells closely resembling neurons found in the brain. According to Dr. Ellis, “Stem cells from teeth have great potential to grow into new brain or nerve cells, and this could potentially assist with treatments of brain disorders, such as stroke.” She goes on to say “ultimately, we want to be able to use a patient’s own stem cells for tailor-made brain therapy that doesn’t have the host rejection issues commonly associated with cell-based therapies. Another advantage is that dental pulp stem cell therapy may provide a treatment option available months or even years after the stroke has occurred.” Current drug treatment therapies for stroke victims must be administered almost immediately following the stroke – within hours. This severely limits their application as most stroke victims don’t have access to these treatments within that timeframe. Continue reading
Peter Couche suffered from a stroke 20 years ago and has since lived with ‘Locked-in Syndrome’. Peter established The Peter Couche Foundation within the Robinson Institute at the University of Adelaide. The foundation raises money to support adult stem cells research on treatments for stroke victims. The University research utilizes the powerful stem cells found in teeth to develop regenerative therapies to address the trauma induced as a result of a stroke. As the research advances, scientists envisage a therapy regiment utilizing autologous [from the patient] dental stem cells.
Stroke is the third largest cause of death and the single largest cause of adult disability in the developed world. The University of Glasgow and ReNeuron are advancing their clinical trial for stroke patients using neuronal stem cells. Approved by the UK Medicines and Healthcare Products Regulatory Agency (MHRA), the procedure involves expanding the stem cells in-vitro [to clinically relevant numbers] and then transplanting them into the individual. Professor Keith Muir, principal investigator in the trial, said: “We are very pleased that the trial is progressing well and that all the patients treated so far have shown no adverse effects.”