Sickle Cell Disease Treated with Stem Cells

Patients with sickle cell anemia have utilized stem cells from their siblings to treat the disease.

Researchers led by Matthew Hsieh of the National Institute of Diabetes and Digestive and Kidney Diseases and the National Heart, Lung, and Blood Institute have reversed sickle cell disease in adults by utilizing stem cells from the patients’ siblings.  The patients received a transplant that combined their own stem cells with those of a sibling, resulting in an increase in lung function and a decrease in the patients’ sickle cell count, as well as their dependency on immunosuppressant and pain relieving drugs. Continue reading

Harnessing the Power of Stem Cells

Scientists have developed a method for increasing the survival rate, and therefore the effectiveness, of transplanted mesenchymal stem cells.

A team of scientists from the Harvard Stem Cell Institute and the Boston Children’s Hospital have developed a method to increase the survival rate, and therefore the effectiveness, of transplanted mesenchymal stem cells [MSCs]. In an animal model, Dr. Juan Melero-Martin and his team of researchers co-transplanted MSCs with blood vessel-forming cells, enabling the stem cells to survive longer in a patient to reach their full regenerative potential.

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Stem Cell Clinical Trials to Treat Genetic Disorders Announced

DNA strand

Gene therapies utilizing stem cells are being developed that may lead to a cure for several genetic diseases. Currently, two clinical trials were announced to treat Cerebral Adrenoleukodystrophy (CCALD) and betathalassemia/sickle cell disease.

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Stem Cell Treatments for Hematological Malignancies Advance to Clinical Testing Phase

 

 

 

 

 

 

 

 

 

 

 

Gamida Cell, a leading adult stem cell therapeutics company has completed enrollment for a Phase I/II trial for hematological malignancies utilizing their NiCord treatment. The treatment is a potential cure for blood cancers, sickle cell disease, thalassemia, severe autoimmune diseases and metabolic diseases. This trial is but one example of the increasing number of stem cell treatments moving out of the lab and entering the clinical testing phase.

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