MSCs and HCELL molecules track down islet cells and reverse inflammation.
According to a recently published study from the Brigham and Woman’s Hospital, mesenchymal stem cells [MSCs] have the ability to reverse type I diabetes by suppressing the auto-immune attack of islet cells. Although the MSCs cannot be directly injected into the pancreas, the researchers utilized the surface adhesion molecule HCELL to hone the stem cells in on the inflamed islets, allowing them to normalize blood sugar levels without the use of insulin. Continue reading →
Scientists have accelerated stem cell differentiation to produce more insulin-producing beta cells.
Harvard University researchers have developed a technique to accelerate stem cell differentiation to produce massive amounts of the insulin-producing beta cells that are destroyed in patients with type-1 or type-2 diabetes. With an ample and readily available supply of beta cells, researchers are developing therapies that may someday allow patients to produce the precise amount of insulin required to control their blood sugar levels naturally – without the use of a pump or insulin shots. Continue reading →
CRISPR may change the way scientists incorporate stem cells for translational genomics.
Scientists led by Dr. Craig Mello of The University of Massachusetts have developed a genetic tool – CRISPR [clustered regularly interspaced short palindromic repeats] – to revolutionize the way stem cells are applied to treat genetic diseases, such as sickle cell or thalassemia. CRISPR aims to expedite and improve upon the process of translational genomics, in which the patient’s stem cells are extracted, altered to repair the damaged gene, and then transplanted back to the patient. Continue reading →
The transplantation of adult stem cells into a Type-1 Diabetes animal model has revealed the importance of blood vessels in pancreatic beta cell regeneration.
Researchers led by Dr. Habib Zaghouani from the University of Missouri have developed a potential cure to Type 1 Diabetes by utilizing mesenchymal stem cells [MSCs]. Although researchers anticipated that the MSCs would differentiate into new insulin producing pancreatic beta cells, they discovered that the stem cells fulfilled the more critical function of repairing damaged blood vessels, which in turn facilitated the regeneration of insulin producing pancreatic beta cells and the distribution of insulin across the body. Continue reading →
Stem cells have been differentiated into pancreatic beta cells, providing a potential treatment for Type 1 Diabetes.
Researchers from the Gladstone Institutes have developed a potential treatment for Type 1 diabetes by differentiating stem cells into insulin-producing pancreatic beta cells. These new cells, when transplanted into animal models, lowered abnormally high glucose levels down to a more healthy level in just one week. Continue reading →
Millions of individuals around the world suffer from type-1 diabetes, three million in the US alone. Researchers at the University of Missouri, led by Dr. Habib Zaghouani, have developed a two pronged approach to curing the disease: they modulate the immune system with a drug that stops it from attacking the pancreas and use stem cells to regenerate and rebuild the insulin producing pancreatic beta cells.
In a pre-clinical trial, Researchers at the National University of Ireland Galway have found that mesenchymal stem cells (MSCs) demonstrate the ability to increase wound healing for diabetics’ related wounds. Diabetic patients have impaired ability to heal wounds with 25% of diabetic patients affected by foot ulcers; which may result in amputation.
Like many forms of chronic disease, diabetes is on the rise in the U.S. and globally. Diabetes causes many complications, a very common symptom being the development of ulcers in feet. Often, this results in the amputation of the foot. In addition, according to Dr. Sankaranarayanan, “if left untreated, patients with diabetic foot ulcer may develop serious cardiac and renal complications.”