Stroke-Induced Brain Damage Prevented by Stem Cells.

Stem cells have been found to prevent neurological damage to GCI stroke victims.

In a recently published study from the Hallym University College of Medicine, researchers have applied mesenchymal stem cells [MSCs] to animal models afflicted with global cerebral ischemia [GCI] to successfully reduce the associated neuronal damage.  When compared to those that received no treatment, animals that received MSCs displayed a significant decrease in cell death, inflammation to the brain, and disruption of the blood brain barrier. Continue reading

The Nose Knows – The Importance of Stem Cells.

Stem cells are regulators for critical connections between the nose and the brain.

Scientists from the National Institute of Neurological Disorders and Stroke have identified neural stem cells as important regulators of the olfactory bulb and its connections to the brain. The researchers discovered that a constant influx of stem cells is required for the olfactory system to function properly.  The removal of stem cells causes a widespread disruption of signals sent to the brain, resulting in sensory deprivation. Continue reading

Schizophrenia Studied With Human Stem Cells.

Scientists have differentiated stem cells into brain cells to study Schizophrenia.

Researchers from the University of California San Diego have differentiated stem cells into neurons to reach a new understanding of the mechanisms of schizophrenia.  The scientists harvested the stem cells of schizophrenia patients, differentiated them into brain cells, and then studied the cells on a dish to reveal that not only do stem cell-derived neurons emit neurotransmitters, but that several of these transmitters, such as dopamine, epinephrine, and norepinephrine, are secreted excessively in patients suffering from schizophrenia. Continue reading

New York Times: The Eruption of Stem Cell Therapies.

Mr. Edgar Irastorza is one of thousands of people already benefiting from the progression of stem cell based therapies.

As reported on the front page of the New York Times Science section, clinical applications of stem cell based therapies are accelerating at a rate that will revolutionize the medical field in a matter of years.  In the United States alone, there are currently over 4000 therapies in clinical trials for the treatment of heart disease, blindness, spinal cord injuries, diabetes, H.I.V., and other diseases, injuries, and traumas. Continue reading

Brain Model Created from Stem Cells.

Researchers from Tufts University utilize stem cells to create a 3-D model of the brain that replicates neurological function.

As reported in a recent article in the New York Times, bioengineers from Tufts University have created a 3-D model of the brain that, utilizing stem cell-derived neurons, the model can mimic the brain’s response to traumatic injury. Principle Investigator Dr. David Kaplan tested the model by dropping weights on it, resulting in a complete neuronal response, including the transmission of electrical impulses and chemical signals through the neurons. Continue reading

Dental Stem Cells Differentiated into Brain-like Cells for Stroke Patients

Scientists have discovered the ability of dental pulp stem cells to grow into brain-like neurons.

Researchers from the University of Adelaide, led by Dr. Kylie Ellis, have discovered that dental pulp stem cells [DPSC] have the ability to differentiate into complex networks of cells closely resembling neurons found in the brain.  According to Dr. Ellis, “Stem cells from teeth have great potential to grow into new brain or nerve cells, and this could potentially assist with treatments of brain disorders, such as stroke.” She goes on to say “ultimately, we want to be able to use a patient’s own stem cells for tailor-made brain therapy that doesn’t have the host rejection issues commonly associated with cell-based therapies. Another advantage is that dental pulp stem cell therapy may provide a treatment option available months or even years after the stroke has occurred.”  Current drug treatment therapies for stroke victims must be administered almost immediately following the stroke – within hours.  This severely limits their application as most stroke victims don’t have access to these treatments within that timeframe. Continue reading

Alzheimer’s Disease Studied with Human Stem Cells

The use of human stem cells could lead to a better understanding of causes and possible treatments for Alzheimer’s Disease

A research team from Aston University has developed a new method to investigate Alzheimer’s disease through the use of human stem cells.  Through the study of tau proteins, this novel use of stem cells can help scientists predict with greater accuracy the effectiveness of different treatments to prevent the onset of Alzheimer’s disease.   Continue reading

Cerebral Palsy Treated With Autologous Stem Cells

A new experimental therapy utilizes stem cells to treat cerebral palsy in children.

Due to the initial success of an experiment conducted by Duke University, doctors in Spain are now attempting a clinical trial in which stem cells are utilized to treat children with cerebral palsy. According to Dr. Luis Mader, the doctor performing the transplants, “Though this type of treatment is still in its very early stages, it is believed that regenerative therapies with stem cells could be a therapeutic option to regenerate the nerve tissue and repair brain damage.” Continue reading

Hypoxic-Ischemic Encephalopathy (HIE) Treated with Dental Pulp Stem Cells

Dental Pulp Stem Cell treatments resulted in improved behavioral and neuronal function

In a recent study, researchers have demonstrated the effectiveness of Dental Pulp Stem Cells (DPSCs) in reversing brain damage caused by Hypoxic-Ischemic Encephalopathy [HIE].  In the animal study, HIE subjects injected with DPSCs showed improvements in behavioral tests and an increase in neuronal markers.  The results indicate that substantive brain function was recovered due to DPSC treatment.  Continue reading

Mesenchymal Stem Cells Prevent Long-Term Damage after Traumatic Brain Injury

Stem Cells are used to regulate inflammation after a TBI.

A study from the University of Texas Health Science Center has discovered a novel function of mesenchymal stem cells in preventing long-term brain damage and inflammation in patients following traumatic brain surgery.  MSCs injected into TBI-mice actually travelled to the spleen to regulate the body’s inflammatory response to the trauma and preserve brain function. Continue reading