Ophthalmologists James L Funderburgh, Ph.D. and Fatima Syed-Picard, Ph.D. from the University of Pittsburgh have devised a method for treating corneal blindness by utilizing dental pulp stem cells. The researchers harvested the stem cells from molars discarded during routine extraction and induced the cells to differentiate into keratocytes [corneal cells]. They then seeded the cells onto a nanofiber scaffold, allowing them to grow into fully developed, functional corneas capable of restoring eyesight. Continue reading
A research team led by Dr. Songtao Shi from the Herman Ostrow School of Dentistry of USC has discovered that mesenchymal stem cells [MSCs] found in the gums are able to regulate the body’s immune system to treat inflammatory diseases. In an animal model suffering from colitis [an inflamed condition of the colon], the scientists were able to transplant these gingival MSCs, significantly reducing the inflammation. Continue reading
Today, stem cells are rightfully perceived as the future of regenerative medicine, set to bring the marvels of science fiction into reality. But in looking ahead at all of the promise that stem cells hold for the future, it becomes easy to miss the scientific advances made to date for the millions of people around the world suffering from disease, trauma, and injury. Thus, today marks Stem Cell Awareness Day: a global celebration of stem cell research coordinated to highlight the treatments and therapies currently in development to create personalized regenerative therapies for patients. Continue reading
Researchers at the Wyss Institute and Harvard School of Engineering and Applied Sciences have developed a self-shrinking gel that, when loaded with mesenchymal stem cells [MSCs], stimulates their ability to differentiate into teeth, bones, and organs in vivo [in the patient’s body]. The gel is designed to spontaneously compress at 37°C [the temperature of the human body], which places the physical pressure required to trigger the stem cells’ proliferative properties while inside the patient’s body. Continue reading
Researchers at the National Institute for Dental and Craniofacial Research have developed a method of utilizing autologous [the patient’s own] dental stem cells to regenerate damaged or decayed teeth. In an animal model, as well as human cells in vitro [in a lab], the scientists treated the damaged teeth with low-intensity lasers, which prompted the stem cells located in the dental pulp to differentiate and grow into new, healthy dentin tissue. Continue reading
Doctors at the All India Institute of Medical Sciences have developed a novel stem cell therapy called “SealBio” to replace traditional root canal treatments. SealBio eliminates the need to clean, shape, and fill the tooth with artificial sealer cement by inducing the stem cells of the root to regenerate adult tissue as a natural biological seal. Over time, this technique can even restore the root canal back to health. Continue reading
Utilizing dental pulp stem cells, researchers at Japan’s National Center for Geriatrics and Gerontology have developed a stem cell treatment for tooth decay by restoring a tooth’s structure and function. In the study, involving canine subjects, researchers utilized the dog’s own dental pulp stem cells to repair damaged and compromised teeth. Given the success of the study, researchers have initiated clinical [human] trials.
- Bone scaffolds
Researchers from University of Nottingham in England had their 3D printing technology on display last week at the Royal Society’s annual Summer Science Exhibition. This technology is being used to create custom-fitted bone replacements and other body parts.
The Wall Street Journal recently reported on current research involving dental pulp stem cells [DPSC]. Researchers worldwide, including StemSave’s Chief Scientific Adviser, Dr. Jeremy Mao of Columbia University, are making advances in restoring tooth tissue and regenerating entire teeth using dental pulp stem cells. Current studies are in the animal model stage but researchers anticipate entering human clinical trials in the near future.
Researchers at the University of California, San Diego and the University of Sheffield have worked together to find a way to improve stem cell scaffolding through sticky spots scattered throughout the extra-cellular matrix. The improvement in scaffolding will lead to better stem cell treatments in many areas. Right now, scaffolds are being used in tandem with stem cells to grow new tracheas, teeth, cartilage, organs and much more.