Bone Regeneration Made Possible With Stem Cells

Epibone creates precisely measured scaffolding for stem cells to recreate damaged bone.

The New York-based startup Epibone intends to begin human testing on a procedure that will utilize stem cells to regenerate living bone tissue.  The researchers, originally from Columbia University, will apply autologous [the patient’s own] stem cells to nanofiber scaffolding of the desired size and shape and direct the stem cells to differentiate into a physical and genetic replica of the patient’s own bone. Continue reading

Bone Regeneration Technique Stimulates Stem Cells with Magnetic Nanoparticles.

Remote controlled nanoparticles may allow stem cells to regenerate bone tissue

Medical researchers from Keele University and Nottingham University have integrated remote controlled magnetic nanoparticles to incite the differentiation of stem cells into new bone tissue for the treatment of bone diseases, disorders, and injuries. In pre-clinical trials, the nanoparticles were coated with proteins that stimulate the stem cells, and then delivered directly to the damaged tissue via an external magnetic field. Continue reading

Game, Set, Match: Tennis Elbow Gets Aced by Stem Cell Therapy

In a new pilot study at the Royal National Orthopaedic Hospital in London, researchers will utilize stem cells to promote the healing of painful tendon injuries such as tennis elbow.  Initial studies suggest that, upon transplantation, the stem cells release growth factors to the point of injury, which induce the growth of new tendon tissue while reducing scar tissue to recover movement and flexibility. Continue reading

Lupus Therapy Incorporates Mesenchymal Stem Cells

Beijing researchers are capitalizing on the abilities of mesenchymal stem cells to reduce inflammation and promote cell growth to combat systemic lupus erythematosus.

In a recent clinical study conducted in Beijing, researchers are testing a treatment for patients suffering from systemic lupus erythematosus by administering autologous [the patient’s own] mesenchymal stem cells.  The researchers aim to capitalize on the unique abilities of MSCs to not only differentiate into a multitude of different cell types, but to reduce the autoimmune attack in patients affected by lupus as well. Continue reading

Gel-Like Polymers May Improve Stem Cell-Based Therapies.

Scientists are developing a polymeric gel to protect stem cells from trauma during transplant injections.

Complex chemical polymers are currently being developed by scientists at Stanford University to protect and support the proliferation of stem cells during spinal cord transplantation procedures.  The gels are designed to provide padding for the cells during injection, while also varying in viscosity and the biochemical signals contained within to offer stem cells an optimal environment for differentiation. Continue reading

Osteoarthritis Stem Cell Treatment in Clinical Trial

The transplantation of stem cells into areas affected by osteoarthritis allow lost cartilage tissue to regenerate.

In recent clinical trials, researchers at the National University of Ireland Galway have successfully utilized adult stem cells to treat patients with osteoarthritis.  The treatment involves recovering the patients’ own [autologous] stem cells and then injecting the stem cells into cartilage to stimulate the regeneration of lost tissue. Continue reading

Stem Cells Utilized to Regulate Extreme Inflammation in Limb Injuries.

Stem cells are being used to reduce extreme inflammation to alleviate strain on the body’s healing process.

Immunologists at the Medical College of Georgia and College of Dental Medicine a Georgia Regents University have developed a method of utilizing autologous [the patient’s own] stem cells to treat Ischemia Reperfusion Injury, a condition in which excessive blood flow to an injury results in severe inflammation and hindered recovery. The stem cells function with a chemical called indoleomine 2,3 Dioxygenase, or IDO, which can regulate the immune response without completely disabling it, allowing the healing process to ensue normally. Continue reading

Mesenchymal Stem Cells [MSC] Promote Nerve Regeneration

neurons

Researchers at Johns Hopkins University, Department of Plastic and Reconstructive Surgery find that mesenchymal stem cells [the type of stem cells found in teeth] promoted nerve regeneration in animal models [in this case – rodents] with paralyzing leg injuries.  According to the researchers, “Mesenchymal stem cells may be a promising add-on therapy to help damaged nerves regenerate.”  The study found that the rodents treated with their own stem cells responded best to the treatment. Those treated with donated cells from dissimilar rodent types – a situation most similar to human transplants – rejected their new limbs.

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