Bone Regeneration Made Possible With Stem Cells

Epibone creates precisely measured scaffolding for stem cells to recreate damaged bone.

The New York-based startup Epibone intends to begin human testing on a procedure that will utilize stem cells to regenerate living bone tissue.  The researchers, originally from Columbia University, will apply autologous [the patient’s own] stem cells to nanofiber scaffolding of the desired size and shape and direct the stem cells to differentiate into a physical and genetic replica of the patient’s own bone. Continue reading

Bone Regeneration Technique Stimulates Stem Cells with Magnetic Nanoparticles.

Remote controlled nanoparticles may allow stem cells to regenerate bone tissue

Medical researchers from Keele University and Nottingham University have integrated remote controlled magnetic nanoparticles to incite the differentiation of stem cells into new bone tissue for the treatment of bone diseases, disorders, and injuries. In pre-clinical trials, the nanoparticles were coated with proteins that stimulate the stem cells, and then delivered directly to the damaged tissue via an external magnetic field. Continue reading

Game, Set, Match: Tennis Elbow Gets Aced by Stem Cell Therapy

In a new pilot study at the Royal National Orthopaedic Hospital in London, researchers will utilize stem cells to promote the healing of painful tendon injuries such as tennis elbow.  Initial studies suggest that, upon transplantation, the stem cells release growth factors to the point of injury, which induce the growth of new tendon tissue while reducing scar tissue to recover movement and flexibility. Continue reading

Gel-Like Polymers May Improve Stem Cell-Based Therapies.

Scientists are developing a polymeric gel to protect stem cells from trauma during transplant injections.

Complex chemical polymers are currently being developed by scientists at Stanford University to protect and support the proliferation of stem cells during spinal cord transplantation procedures.  The gels are designed to provide padding for the cells during injection, while also varying in viscosity and the biochemical signals contained within to offer stem cells an optimal environment for differentiation. Continue reading

Osteoarthritis Stem Cell Treatment in Clinical Trial

The transplantation of stem cells into areas affected by osteoarthritis allow lost cartilage tissue to regenerate.

In recent clinical trials, researchers at the National University of Ireland Galway have successfully utilized adult stem cells to treat patients with osteoarthritis.  The treatment involves recovering the patients’ own [autologous] stem cells and then injecting the stem cells into cartilage to stimulate the regeneration of lost tissue. Continue reading

Cartilage Regeneration Method Promises Rapid Knee Repair

Stem Cells could make knee cartilage repair more convenient and 75% less expensive.

Researchers in the Netherlands at UMC Utrecht have developed a method to combine two chondrocyte knee repair surgeries into one using mesenchymal stem cells (MSCs).  The new procedure takes chondrocytes (cells found in cartilage) from the patient, mixes them with specialized MSCs, and then implants them back into the damaged area of the knee.  The stem cells help regenerate the cartilage, while the patient’s own cells avoid an immune response when implanting the mixture. Continue reading

Columbia University Advances Stem Cell Based Approach to Repairing a Torn ACL

Stem cells could be used to expedite the healing process of a torn ACL

Researchers in the Biomedical Engineering Department at Columbia University have developed a methodology utilizing mesenchymal stem cells [the type of stem cells found in teeth] to engineer fibroblast tissue in the ACL. The stem cells were treated with both chemical growth factors and mechanical factors [scaffolding and mechanical stimuli], which enhanced the regeneration of connective tissue. Continue reading

Treating Arthritis with Stem Cells

damaged knee and mesenchymal stem cells

Arthritis affects 44 million individuals in the US resulting in the need for approximately 700,000 knee-replacement and 100,000 hip replacement surgeries every year. Researchers at Stanford University have developed a technique to track the effectiveness of mesenchymal stem cells [the type of stem cells found in teeth] in repairing arthritic joints. Mesenchymal stem cells are capable of differentiating into bone and cartilage, as well as muscle, fat and tendon.  The researchers expect to adapt the study for clinical trials in humans this fall.

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