Tipping the Scales: Stem Cells May Help Prevent Obesity and More.

Scientists have found that the alteration of stem cell cilia can have a positive effect on weight loss.

 

In a recently published study from the Queen Mary University of London, scientists discovered a connection between the length of cilia [hair-like projections for cell movement] on stem cells and their proclivity towards differentiating into fat cells.  By restricting the elongation of stem cell cilia, the researchers were able to impede on the formation of new fat cells. Continue reading

Bone Regeneration Made Possible With Stem Cells

Epibone creates precisely measured scaffolding for stem cells to recreate damaged bone.

The New York-based startup Epibone intends to begin human testing on a procedure that will utilize stem cells to regenerate living bone tissue.  The researchers, originally from Columbia University, will apply autologous [the patient’s own] stem cells to nanofiber scaffolding of the desired size and shape and direct the stem cells to differentiate into a physical and genetic replica of the patient’s own bone. Continue reading

Bone Regeneration Technique Stimulates Stem Cells with Magnetic Nanoparticles.

Remote controlled nanoparticles may allow stem cells to regenerate bone tissue

Medical researchers from Keele University and Nottingham University have integrated remote controlled magnetic nanoparticles to incite the differentiation of stem cells into new bone tissue for the treatment of bone diseases, disorders, and injuries. In pre-clinical trials, the nanoparticles were coated with proteins that stimulate the stem cells, and then delivered directly to the damaged tissue via an external magnetic field. Continue reading

Inflammatory Disease Healed with Stem Cells

Stem cells located in the gums have the ability to regulate inflammatory conditions.

A research team led by Dr. Songtao Shi from the Herman Ostrow School of Dentistry of USC has discovered that mesenchymal stem cells [MSCs] found in the gums are able to regulate the body’s immune system to treat inflammatory diseases.  In an animal model suffering from colitis [an inflamed condition of the colon], the scientists were able to transplant these gingival MSCs, significantly reducing the inflammation. Continue reading

Lupus Therapy Incorporates Mesenchymal Stem Cells

Beijing researchers are capitalizing on the abilities of mesenchymal stem cells to reduce inflammation and promote cell growth to combat systemic lupus erythematosus.

In a recent clinical study conducted in Beijing, researchers are testing a treatment for patients suffering from systemic lupus erythematosus by administering autologous [the patient’s own] mesenchymal stem cells.  The researchers aim to capitalize on the unique abilities of MSCs to not only differentiate into a multitude of different cell types, but to reduce the autoimmune attack in patients affected by lupus as well. Continue reading

Osteoarthritis Stem Cell Treatment in Clinical Trial

The transplantation of stem cells into areas affected by osteoarthritis allow lost cartilage tissue to regenerate.

In recent clinical trials, researchers at the National University of Ireland Galway have successfully utilized adult stem cells to treat patients with osteoarthritis.  The treatment involves recovering the patients’ own [autologous] stem cells and then injecting the stem cells into cartilage to stimulate the regeneration of lost tissue. Continue reading

Stem Cells Immune to Damage from Leukemia Chemotherapy

Certain stem cells have been found to be immune to the bone-degenerative side effects of chemotherapy used against leukemia.

A research team, led by Dr. Eric Darling of Brown University, has found a potential source of stem cells to protect children with acute lymphoblastic leukemia against the adverse effects of the chemotherapy drug methotrexate (MTX).  Adipose-derived stem cells, which appear to be impervious to the bone-degenerative side effects of MTX, may allow children to undergo the chemotherapy treatment and then regain the lost bone tissue afterwards. Continue reading

Growing Teeth with Mesenchymal Stem Cells

Scientists are using mesenchymal stem cells to grow new organs in vivo.

Researchers at the Wyss Institute and Harvard School of Engineering and Applied Sciences have developed a self-shrinking gel that, when loaded with mesenchymal stem cells [MSCs], stimulates their ability to differentiate into teeth, bones, and organs in vivo [in the patient’s body]. The gel is designed to spontaneously compress at 37°C [the temperature of the human body], which places the physical pressure required to trigger the stem cells’ proliferative properties while inside the patient’s body. Continue reading

Bone Reconstruction Technique Utilizes Autologous Stem Cells

Stem cells are allowing doctors to personalize treatments to repair damaged or diseased bone.

A team of medical researchers at Saint Luc University Clinic have developed a method of repairing bones utilizing autologous [the patient’s own] stem cells.  The process involves harvesting the stem cells from the patient, differentiating the stem cells in-vitro to grow bone, pairing the cells with a scaffolding matrix and then molding the material to repair damaged or diseased bone within the patient. Continue reading

Osteogenesis Imperfecta Treatment with Mesenchymal Stem Cells

Mesenchymal Stem Cell treatment has been shown to improve bone tissue formation in babies with osteogenesis imperfecta.

Researchers from Karolinska Institutet’s Department of Clinical Sciences have developed an application for mesenchymal stem cells [the same type found in Dental Stem Cells] to provide treatment for children born with osteogenesis imperfecta.  The researchers utilized the unique properties of MSCs to facilitate and improve bone tissue formation through in utero transplantations. Continue reading