The New York-based startup Epibone intends to begin human testing on a procedure that will utilize stem cells to regenerate living bone tissue. The researchers, originally from Columbia University, will apply autologous [the patient’s own] stem cells to nanofiber scaffolding of the desired size and shape and direct the stem cells to differentiate into a physical and genetic replica of the patient’s own bone. Continue reading
Medical researchers from Keele University and Nottingham University have integrated remote controlled magnetic nanoparticles to incite the differentiation of stem cells into new bone tissue for the treatment of bone diseases, disorders, and injuries. In pre-clinical trials, the nanoparticles were coated with proteins that stimulate the stem cells, and then delivered directly to the damaged tissue via an external magnetic field. Continue reading
According to new research from the Stowers Institute for Medical Research, hematopoietic stem cells [stem cells that produce blood] are directly regulated by megakaryocytes, the blood cells responsible for healing wounds. The researchers found that megakaryotes produce two growth factors; one that signals for hematopoietic stem cells to proliferate, and one that keeps them in an inactive state. This relationship controls the amount of blood being produced in the body. Continue reading
As reported on the front page of the New York Times Science section, clinical applications of stem cell based therapies are accelerating at a rate that will revolutionize the medical field in a matter of years. In the United States alone, there are currently over 4000 therapies in clinical trials for the treatment of heart disease, blindness, spinal cord injuries, diabetes, H.I.V., and other diseases, injuries, and traumas. Continue reading
A research team, led by Dr. Eric Darling of Brown University, has found a potential source of stem cells to protect children with acute lymphoblastic leukemia against the adverse effects of the chemotherapy drug methotrexate (MTX). Adipose-derived stem cells, which appear to be impervious to the bone-degenerative side effects of MTX, may allow children to undergo the chemotherapy treatment and then regain the lost bone tissue afterwards. Continue reading
A team of medical researchers at Saint Luc University Clinic have developed a method of repairing bones utilizing autologous [the patient’s own] stem cells. The process involves harvesting the stem cells from the patient, differentiating the stem cells in-vitro to grow bone, pairing the cells with a scaffolding matrix and then molding the material to repair damaged or diseased bone within the patient. Continue reading
Researchers from Karolinska Institutet’s Department of Clinical Sciences have developed an application for mesenchymal stem cells [the same type found in Dental Stem Cells] to provide treatment for children born with osteogenesis imperfecta. The researchers utilized the unique properties of MSCs to facilitate and improve bone tissue formation through in utero transplantations. Continue reading
Researchers at Melbourne’s St. Vincent Hospital and the University of Wollongong are engineering a device known as the “Biopen” to deliver stem cells to damaged or diseased bones. This novel method of stem cell therapy administers a mixture of jelly and stem cells into the damaged sections of the bone. The jelly is then UV-dried into a scaffolding to facilitate stem cell growth and bone regeneration.
A study team from Kobe University Graduate School of Medicine in Japan has developed a treatment for hard to heal bone fractures. The treatment makes use of autologous [the patient’s own] stem cells to promote proper healing in fractures that fail to heal on their own. Continue reading
In a follow-up study, stem cells from teeth were found to provide a viable and stable repair mechanism for mandibular bone defects. Three years after the clinical trial was initiated, the bone is still functioning properly.