Atherosclerotic Lesions Prevented by MSCs

Stem cells were found to reduce plaque in patients with atherosclerosis.

According to new research from the National Yang-Ming University, mesenchymal stem cells [MSCs] hold the ability to limit atherosclerotic plaque formation, thereby preventing the onset of harmful endothelial lesions. The research team, led by Shih-Chieh Hung, transplanted MSCs into animal models with atherosclerosis and observed significant reduction in plaque formation. They also saw an increase in blood vessel dilation, which prevents further plaque development, indicating good endothelial health. Continue reading

Low Blood Cell Counts Could Be Treated by Regulating Stem Cells.

Megakaryotes may hold the ability to regulate the amount of blood that stem cells produce.

According to new research from the Stowers Institute for Medical Research, hematopoietic stem cells [stem cells that produce blood] are directly regulated by megakaryocytes, the blood cells responsible for healing wounds.  The researchers found that megakaryotes produce two growth factors; one that signals for hematopoietic stem cells to proliferate, and one that keeps them in an inactive state.  This relationship controls the amount of blood being produced in the body. Continue reading

Blood Cells Generated by Modified Stem Cell Differentiation

Researchers have identified two transcription factors that induce stem cells to differentiate into blood cells.

A research group led by Dr. Igor Slukvin, MD PHD, from University of Wisconsin-Madison has identified two transcription factors responsible for the differentiation of stem cells into numerous types of white and red blood cells.  The team made use of messenger RNA to overexpress the two transcription factors, which allowed them to generate 30 million blood cells for every million stem cells, without the use of a virus or altering the genetic structure of the blood. Continue reading

Gel-Like Polymers May Improve Stem Cell-Based Therapies.

Scientists are developing a polymeric gel to protect stem cells from trauma during transplant injections.

Complex chemical polymers are currently being developed by scientists at Stanford University to protect and support the proliferation of stem cells during spinal cord transplantation procedures.  The gels are designed to provide padding for the cells during injection, while also varying in viscosity and the biochemical signals contained within to offer stem cells an optimal environment for differentiation. Continue reading

Type 1 Diabetes Treatment Advance Utilizes Mesenchymal Stem Cells

The transplantation of adult stem cells into a Type-1 Diabetes animal model has revealed the importance of blood vessels in pancreatic beta cell regeneration.

Researchers led by Dr. Habib Zaghouani from the University of Missouri have developed a potential cure to Type 1 Diabetes by utilizing mesenchymal stem cells [MSCs].  Although researchers anticipated that the MSCs would differentiate into new insulin producing pancreatic beta cells, they discovered that the stem cells fulfilled the more critical function of repairing damaged blood vessels, which in turn facilitated the regeneration of insulin producing pancreatic beta cells and the distribution of insulin across the body. Continue reading

Improving the Efficacy of Hematopoietic Stem Cells.

The protein SIRT1 maintains the regenerative abilities of hematopoietic stem cells.

A research team from Mount Sinai, Harvard Medical School, and Children’s Hospital in Boston has determined the function of protein Sirtuin1 (SIRT1) in maintaining the regenerative ability of blood stem cells.  The researchers found that young stem cells lacking SIRT1 exhibited a similar deficiency in rejuvenating blood as observed in older stem cells.  These older, defunct blood stem cells are unable to refresh the body’s blood supply, resulting in vulnerability to age-related cancers and immune diseases. Continue reading

Unique Properties of Mesenchymal Stem Cells Promotes Growth of New Blood Vessels

MSCs can promote other stem cells into organizing into new tissues, organs, and vascularization.

Researchers at University of Illinois at Chicago have discovered an ability of mesenchymal stem cells [the type of stem cells found in teeth] to facilitate the growth of new blood vessels.  MSCs promotion of vascularization is critical, not only for the repair of damaged tissue and organs, but for the development of new organs as well. Continue reading

Science Channel Program ‘Futurescape’ Reports on Stem Cells and Life Extension

The Science Channel explores the use of stem cells in regenerative medicine

As seen on the Science Channel’s “Futurescape” program, the host of the program, James Woods takes viewers on a journey of discovery as he explores the field of regenerative medicine and life extension.   The program examines current and future applications of stem cells to grow organs and tissue to treat disease, trauma and injury as well as efforts to increase life expectancy and mitigate the effects of aging. Continue reading

The Future of Regenerative Medicine is Now – Creating Organs With Your Own Stem Cells

Dr. Seifalian

 

 

 

 

 

 

 

Researchers all around the world are working towards utilizing stem cells to grow replacement organs. While once thought to be a futuristic concept, it is now very real. Doctors and researchers have successfully transplanted lab grown bladders, blood vessels, tear ducts, arteries and windpipes. Now, research teams around the world are growing urethras, bile ducts, larynxes, bones, livers, kidneys, and even hearts.

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