Stem Cells Immune to Damage from Leukemia Chemotherapy

Certain stem cells have been found to be immune to the bone-degenerative side effects of chemotherapy used against leukemia.

A research team, led by Dr. Eric Darling of Brown University, has found a potential source of stem cells to protect children with acute lymphoblastic leukemia against the adverse effects of the chemotherapy drug methotrexate (MTX).  Adipose-derived stem cells, which appear to be impervious to the bone-degenerative side effects of MTX, may allow children to undergo the chemotherapy treatment and then regain the lost bone tissue afterwards. Continue reading

Heat Stroke Treatment Utilizes Dental Pulp Stem Cells

Scientists have treated heat-induced brain damage with stem cells.

A team of researchers at the Kaohsiung Medical University School of Dentistry have found that intravenous transplantation of dental pulp stem cells can protect against brain damage in heat stroke patients.  Utilizing an animal model, scientists administered the treatment immediately post-heat stroke and observed several therapeutic effects, including a decrease in neurological damage, inflammation, and oxidative stress to the brain. Continue reading

Osteoarthritis Treatment Utilizes Autologous Stem Cells

Researchers have found a way to use a patient’s own stem cells to ease the pain of osteoarthritis.

In a recent Phase 1 Clinical Trial, a team of researchers at the National University of Ireland, Galway, were successful in developing a treatment for osteoarthritis that utilizes autologous [the patient’s own] stem cells. According to Professor Frank Barry, scientific director of the Regenerative Medicine Institute at NUI Galway, “Using the patient’s own stem cells we have been able to treat their diseased joints and relieve their suffering and burden of pain.” Continue reading

New Stem Cell Therapy Heard Loud and Clear

A new understanding of stem cell pathways can accelerate advances in reversing hearing loss.

Scientists from Harvard Medical School and the Massachusetts Eye and Ear Infirmary have found a signaling pathway that, when blocked, prevents the onset of noise-induced hearing loss and deafness.  In an animal model, the inhibition of the pathway allowed stem cells in the inner ear to differentiate and regenerate sound-sensing hair cells, which are integral to the ability to hear. Continue reading

Osteogenesis Imperfecta Treatment with Mesenchymal Stem Cells

Mesenchymal Stem Cell treatment has been shown to improve bone tissue formation in babies with osteogenesis imperfecta.

Researchers from Karolinska Institutet’s Department of Clinical Sciences have developed an application for mesenchymal stem cells [the same type found in Dental Stem Cells] to provide treatment for children born with osteogenesis imperfecta.  The researchers utilized the unique properties of MSCs to facilitate and improve bone tissue formation through in utero transplantations. Continue reading

Alliance for Regenerative Medicine Annual Conference

The State of the Industry Briefing will review recent financial and clinical successes in stem cell research, as well as the field’s expectations in the new year.

The Alliance for Regenerative Medicine will be hosting the 4th Annual Regenerative Medicine Sate of the Union Briefing on January 13th in San Francisco.  The public briefing will provide an in depth analysis of recent advances in stem cell therapy and the industry’s outlook for 2014.  Continue reading

Autologous Stem Cells Promote Proper Bone Healing

Autologous stem cells eliminate the risk of bone loss and infection in hard to heal bone fractures

A study team from Kobe University Graduate School of Medicine in Japan has developed a treatment for hard to heal bone fractures. The treatment makes use of autologous [the patient’s own] stem cells to promote proper healing in fractures that fail to heal on their own. Continue reading

Utilizing a Patient’s Stem Cells to Avoid Rejection in Organ Transplants

Infusing stem cells into an organ structure allows it to be recognized by the patient’s immune system

Harvard Apparatus Regenerative Technology has developed a method to prevent rejection of organ donations without suppressing the patient’s immune system.  By replacing the donor organ’s original cells with the patient’s own stem cells, the researchers can transplant the organ without an immune response.  This avoids the need to place the patient in an immuno-compromised (vulnerable to disease) state.  The method has successfully been utilized to replace cancerous tracheas and the company is expanding its methodology to other organs. Continue reading